1 (a) Fig. 1.1 is a diagram of the female reproductive system. A B C D E Fig. 1.1 (i) State the letter from Fig. 1.1 that shows the part where: fertilisation occurs … gametes are produced. … [2] (ii) Identify the part labelled B in Fig. 1.1. … [1] (b) Fig. 1.2 shows a student’s description of fertilisation in humans. The description of fertilisation in humans is incorrect. Circle the two incorrect words in the description in Fig. 1.2. Fertilisation is the separation of the nuclei from a sperm cell and an ovary cell. Fig. 1.2 [2] (c) Fig. 1.3 shows how the thickness of the uterus lining changes during the menstrual cycle. 0 2 4 6 8 10 12 14 day of menstrual cycle 16 18 20 22 24 26 28 relative thickness of uterus lining Fig. 1.3 Table 1.1 represents the days during an average menstrual cycle. Table 1.1 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 Use Fig. 1.3 and your own knowledge to: (i) place ticks (3) in Table 1.1 to show the days when the uterus lining is shed [1] (ii) place crosses (✗) in Table 1.1 to show the days when the uterus lining is at its thickest. [1] (d) Complete the sentence to define the term reproduction. Reproduction is the processes that make … of the same … of organism. [2] [Total: 9]

1(a)(i) A ; E ; 2 1(a)(ii) uterus ; 1 1(b) separation ; ovary; 2 1(c)(i)  under days 1–4 ; 1 1(c)(ii) X under days 24–26 ; 1 1(d) more ; kind ; 2

1 (a) Fig. 1.1 is a diagram of a single‑celled organism called a euglena. nucleus flagella pellicle (membrane) chloroplast Fig. 1.1 (i) Table 1.1 shows some of the cell components of animal, euglena and plant cells. Complete Table 1.1 by placing ticks (3) to show the correct cell components of each type of cell. Use the information in Fig. 1.1 and your knowledge to answer the question. Table 1.1 type of cell cell component cell wall chloroplast nucleus vacuole animal euglena plant [3] (ii) State evidence from Fig. 1.1 for and against euglena being a plant cell. evidence for … … evidence against … … [2] (b) State the function of the nucleus. … … [1] (c) The length of a palisade cell is 0.08 mm. The length of a red blood cell is 0.007 mm. Calculate how many times bigger a palisade cell is than a red blood cell. Give your answer to the nearest whole number. … [2] (d) Fig. 1.2 shows a type of nerve cell (neurone). Fig. 1.2 (i) Name the type of neurone shown in Fig. 1.2. … [1] (ii) The type of neurone shown in Fig. 1.2 can be 1.5 m in length. Suggest why these cells need to be very long. … … … [1] [Total: 10]

1(a)(i) type of cell cell wall chloroplast nucleus vacuole animal  euglena   plant     ;;; 3 1(a)(ii) for: euglena has chloroplasts ; against: euglena does not have, cell wall / vacuole ; 2 1(b) controls cells activities or contains, genetic material / DNA ; 1 1(c) 0.08÷ 0.007 or 11.428 ; 11 ; 2 1(d)(i) sensory (neurone) ; 1 1(d)(ii) transmit impulses, over large, areas / distances / AW ; 1

4 (a) Fig. 4.1 is a diagram of the heart. A B C E D Fig. 4.1 (i) Identify the parts labelled B, C and D in Fig. 4.1. B … C … D … [3] (ii) Describe the function of the structure labelled E. … … [1] (iii) The blood vessel labelled A is an artery. Describe the role of arteries in the circulatory system. … … [1] (b) Name two of the main components of blood. 1 … 2 … [2] (c) A student measures their heart rate over a 24‑hour period. Fig. 4.2 shows a graph of the results. 00:00 02:00 04:00 06:00 08:00 10:00 12:00 14:00 16:00 18:00 20:00 22:00 24:00 midnight midday time of day / hours midnight 60 80 100 120 140 160 180 200 heart rate / bpm Fig. 4.2 (i) Calculate the difference in heart rate between the minimum and maximum heart rate seen in Fig. 4.2. …bpm [1] (ii) At 10:00 hours the student attends a fitness class. Estimate the length of time of the fitness class. …hours [1] (iii) At 18:00 hours the student was scared by a snake. Describe and explain the result seen at 18:00 hours in Fig. 4.2. Use ideas about hormones in your answer. … … … … [2] [Total: 11]

4(a)(i) septum ; muscle / muscle wall ; ventricles ; 3 4(a)(ii) ensure one-way flow of blood ; 1 4(a)(iii) transport blood away from the heart ; 1 4(b) any two from red (blood) cells ; white (blood) cells ; platelets ; plasma ; max 2 2 4(c)(i) 110 (bpm) ; 1 4(c)(ii) 4 (hours) ; 1 4(c)(iii) (rapid) increase of heart rate / increase by 70 bpm / increase to 140 bpm ; ref to adrenaline ; 2

4 (a) Fig. 4.1 is a diagram of the heart. A B C E D Fig. 4.1 (i) Identify the parts labelled B, C and D in Fig. 4.1. B … C … D … [3] (ii) Describe the function of the structure labelled E. … … [1] (iii) The blood vessel labelled A is an artery. Describe the role of arteries in the circulatory system. … … [1] (b) Name two of the main components of blood. 1 … 2 … [2] (c) A student measures their heart rate over a 24‑hour period. Fig. 4.2 shows a graph of the results. 00:00 02:00 04:00 06:00 08:00 10:00 12:00 14:00 16:00 18:00 20:00 22:00 24:00 midnight midday time of day / hours midnight 60 80 100 120 140 160 180 200 heart rate / bpm Fig. 4.2 (i) Calculate the difference in heart rate between the minimum and maximum heart rate seen in Fig. 4.2. …bpm [1] (ii) At 10:00 hours the student attends a fitness class. Estimate the length of time of the fitness class. …hours [1] (iii) At 18:00 hours the student was scared by a snake. Describe and explain the result seen at 18:00 hours in Fig. 4.2. Use ideas about hormones in your answer. … … … … [2] [Total: 11]

4(a)(i) septum ; muscle / muscle wall ; ventricles ; 3 4(a)(ii) ensure one-way flow of blood ; 1 4(a)(iii) transport blood away from the heart ; 1 4(b) any two from red (blood) cells ; white (blood) cells ; platelets ; plasma ; max 2 2 4(c)(i) 110 (bpm) ; 1 4(c)(ii) 4 (hours) ; 1 4(c)(iii) (rapid) increase of heart rate / increase by 70 bpm / increase to 140 bpm ; ref to adrenaline ; 2

Cambridge IGCSE Co-ordinated Sciences · 0654

IGCSE Co-ordinated Sciences (0654) Coordination and response past paper questions

Revise IGCSE Co-ordinated Sciences (0654) — Coordination and response with real Cambridge past-paper questions grouped by topic, each shown with its marking scheme. Working one topic at a time targets exactly the skill each question tests.

124 free questions from 2016–2021, each with its marking scheme. Open the full topical bank to filter by subtopic, paper, and year.

Coordination and response in IGCSE Co-ordinated Sciences 0654 exams, 2020–2025

Across 2020–2025, Coordination and response accounted for 149 questions worth 732 marks in Cambridge IGCSE Co-ordinated Sciences (0654) papers.

By year
Year	Questions	Marks
2020	21	95
2021	31	181
2022	24	114
2023	22	99
2024	27	137
2025	24	106

Most-tested subtopics

B13.1 Coordination and response443 marks
B13.2 Hormones322 marks
B13.3 Homeostasis218 marks

Appears in

Paper 1 · 40 qs
Paper 2 · 41 qs
Paper 3 · 29 qs
Paper 4 · 28 qs
Paper 5 · 3 qs
Paper 6 · 8 qs

All most-tested Co-ordinated Sciences topics

2021 May/Jun · Paper 3 · Q1 · 9 marks
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2021 Oct/Nov · Paper 3 · Q1 · 10 marks
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2021 May/Jun · Paper 3 · Q4 · 11 marks
Marking scheme
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2021 May/Jun · Paper 3 · Q4 · 11 marks
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2021 Feb/Mar · Paper 1 · Q9 · 1 mark
Marking scheme
Mark scheme — 2021 Paper 1 Q9
Answer: D
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