1 (a) Fig. 1.1 shows some of the organs of the human body. … X … … Fig. 1.1 (i) Complete the labels in Fig. 1.1 to show the names of the organs. [3] (ii) One function of organ X is digestion. State one other function of organ X. … [1] (iii) Name the organ that pumps blood around the body. … [1] (iv) Name the part of the body where egestion occurs. … [1] (b) Enzymes are involved in digestion. Fig. 1.2 is a graph that shows the effect of pH on the activity of three enzymes. 1 0 2 3 4 5 6 pH enzyme activity enzyme A enzyme B enzyme C 7 8 9 10 11 Fig. 1.2 (i) Describe the effect of pH on enzyme A. Use data from the graph in your answer. … … … … [2] (ii) The mouth has an average pH of 6.7. Identify which enzyme in Fig. 1.2 is found in the mouth. Explain your answer. enzyme … explanation … … [2] (iii) Enzymes are involved in the clotting of blood. Circle the component of blood which is also involved in clotting. plasma platelets red blood cells white blood cells [1] [Total: 11]

1(a)(i) lung(s) ; liver ; large intestine ; 3 1(a)(ii) absorption ; 1 1(a)(iii) heart ; 1 1(a)(iv) anus ; 1 1(b)(i) activity increases then decreases (as pH increases) ; maximum activity at pH 2 ; 2 1(b)(ii) B ; maximum activity at pH 6.5 / other enzymes do not work at pH 6.7 ; 2 1(b)(iii) platelets (circled) ; 1

1 (a) Fig. 1.1 is a diagram of the circulatory system in humans. Y X lungs heart body tissues Fig. 1.1 (i) The arrows show the direction of blood flow through the blood vessels. Blood vessels X and Y are two of the main blood vessels attached to the heart. Identify blood vessels X and Y shown in Fig. 1.1. X … Y … [2] (ii) State the function of the heart. … [1] (iii) Circle the name of the tube that connects the lungs to the nose and mouth. alveoli bronchi bronchiole larynx trachea [1] (b) Complete these sentences about the blood. Choose words from the list. Each word may be used once, more than once or not at all. chlorophyll glucose haemoglobin nitrogen oxygen phagocytosis egestion There are two types of blood cells, red blood cells and white blood cells. Red blood cells transport the gas, … . The gas binds to a chemical in red blood cells called … . White blood cells produce antibodies. White blood cells are also involved in the process of … . [3] (c) Fig. 1.2 shows the pulse rate of a person doing different activities. 0 20 40 60 80 100 120 140 160 pulse rate / beats per minute sitting standing walking running slowly jumping running fast type of activity Fig. 1.2 (i) Place a tick (3) in one box to show the activity that results in a pulse rate of between 120 and 140 beats per minute. jumping sitting running fast standing running slowly walking [1] (ii) Calculate the difference in pulse rate between sitting and running fast. pulse rate sitting = … beats per minute pulse rate running fast = … beats per minute difference in pulse rate = … beats per minute [2] (iii) Describe how the person’s breathing is different when walking compared to jumping. … … [2] [Total: 12]

1(a)(i) aorta ; vena cava ; 2 1(a)(ii) pump blood ; 1 1(a)(iii) trachea ; 1 1(b) oxygen ; haemoglobin ; phagocytosis ; 3 1(c)(i) running slowly box ticked ; 1 1(c)(ii) reading values from graph 60 and 150 ; correct subtraction / 90 ; 2 1(c)(iii) lower breathing rate / AW ; lesser depth of breathing / AW ; 2

4 (a) A student investigates the effect of temperature on enzyme activity. They use an enzyme called amylase to breakdown starch into a reducing sugar. They measure the activity of the enzyme at different temperatures. Fig. 4.1 is a graph of their results. rate of reaction / arbitrary units temperature / °C 0 0 10 20 30 40 50 60 5 10 15 20 25 30 35 Fig. 4.1 (i) Describe the effect of temperature on the enzyme activity shown in Fig. 4.1. Include data from the graph in your answer. … … … … [2] (ii) Complete this sentence to define the term enzyme. Enzymes are … that function as biological … . [2] (iii) Enzymes are transported in the blood plasma. State the molecule in red blood cells that transports oxygen. … [1] (b) Glucose is made by plants during photosynthesis, transported as sucrose and stored as starch. Fig. 4.2 shows apparatus used to investigate one factor that affects photosynthesis. green plant chemical used to remove carbon dioxide from the glass jar water glass jar air tight bung sunlight Fig. 4.2 (i) Place a tick (✓) in one box to show the factor being investigated in Fig. 4.2. carbon dioxide chlorophyll light water [1] (ii) The plant is left for 48 hours in the glass jar. After 48 hours a leaf is prepared and then tested using iodine solution. Complete these sentences about the expected result. When placed on the leaf the iodine solution will be … in colour. This is because the plant does not make any … . [2] (iii) State the name of the ions needed to make chlorophyll. … [1] [Total: 9]

4(a)(i) as temperature increases, rate increases then falls ; peak or optimum (rate) at 40°C / maximum rate 34 (arbitrary units) ; OR activity increases, to 40°C / from a rate of 8 to 34 ; above 40°C the activity decreases / decreases from 34 ; 2 4(a)(ii) proteins ; catalysts ; 2 4(a)(iii) haemoglobin ; 1 4(b)(i) carbon dioxide  chlorophyll light water ; 1 4b(ii) orange / brown ; starch ; 2 4(b)(iii) magnesium ; 1 (a)(i) You need to describe the trend of the rate increasing then falling as temperature increases, and include specific data from the graph, such as the peak or optimum rate at 40°C or the maximum rate of 34 arbitrary units. (a)(ii) You must correctly identify enzymes as 'proteins' and state that they function as biological 'catalysts'. (a)(iii) You need to state 'haemoglobin' as the molecule in red blood cells that transports oxygen. (b)(i) You must correctly identify 'carbon dioxide' and 'water' as the reactants and 'chlorophyll' and 'light' as the conditions for photosynthesis. (b)(ii) You need to state that the iodine solution will turn 'orange' or 'brown' and that this indicates the presence of 'starch'. (b)(iii) You must identify 'magnesium' as the mineral ion needed to make chlorophyll.

4 (a) (i) The boxes on the left show different components of blood. The boxes on the right show functions of the components. Draw one straight line from each component of the blood to its function. component of blood function plasma transport oxygen platelets transport hormones red blood cells clotting the blood [2] (ii) Fig. 4.1 shows both red and white blood cells as seen using a light microscope. Fig. 4.1 Identify one structure found in white blood cells that is not found in red blood cells. Use Fig. 4.1 to help you. … [1] (b) Cancer can affect the components of the blood. There are different types of cancer that affect the blood. Fig. 4.2 shows the percentage of people that survived four different blood cancers, A, B, C and D in 1992 and 2008. A B C D 0 10 percentage of people that survive 5 years after treatment for cancer type of blood cancer 1992 2008 20 30 40 50 60 70 80 90 Fig. 4.2 (i) Identify the blood cancer with the best survival rate in both 1992 and 2008. … [1] (ii) Blood cancer B can stop white blood cells functioning correctly. Explain why someone with blood cancer B finds it more difficult to fight infections. … … … … [2] (c) Hepatitis is a sexually transmitted infection that can be passed on through body fluids and infected blood. (i) One way to prevent the spread of hepatitis is using sterilised needles. State two other ways to prevent the spread of hepatitis. 1 … 2 … [2] (ii) Name one other sexually transmitted infection. … [1] [Total: 9]

4(a)(i) plasma transport oxygen platelets transport hormones red blood cells clotting the blood ;; all correct = 2 marks one or two correct = 1 mark 2 4(a)(ii) nucleus ; 1 4(b)(i) D ; 1 4(b)(ii) idea of not being able to make antibodies ; idea of not being able to engulf microbes / not able to carry out phagocytosis ; 2 4(c)(i) any two from: abstinence from, sex / sexual intercourse ; use of condom / femidom ; blood screening ; not sharing (syringe) needles ; gloves used by health professionals ; better education / raise awareness ; 2 4(c)(ii) HIV / AIDS ; 1

Cambridge IGCSE Combined Science · 0653

IGCSE Combined Science (0653) Transport in animals past paper questions

Revise IGCSE Combined Science (0653) — Transport in animals with real Cambridge past-paper questions grouped by topic, each shown with its marking scheme. Working one topic at a time targets exactly the skill each question tests.

134 free questions from 2016–2021, each with its marking scheme. Open the full topical bank to filter by subtopic, paper, and year.

Transport in animals in IGCSE Combined Science 0653 exams, 2020–2025

Across 2020–2025, Transport in animals accounted for 124 questions worth 672 marks in Cambridge IGCSE Combined Science (0653) papers.

By year
Year	Questions	Marks
2020	18	91
2021	19	128
2022	23	141
2023	25	117
2024	24	122
2025	15	73

Most-tested subtopics

B9.2 Heart372 marks
B9.4 Blood353 marks
B9.3 Blood vessels268 marks

Appears in

Paper 1 · 19 qs
Paper 2 · 38 qs
Paper 3 · 38 qs
Paper 4 · 28 qs
Paper 6 · 1 q

All most-tested Combined Science topics

2021 Feb/Mar · Paper 3 · Q1 · 11 marks
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2021 Oct/Nov · Paper 3 · Q1 · 12 marks
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2021 May/Jun · Paper 3 · Q4 · 9 marks
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2021 May/Jun · Paper 3 · Q4 · 9 marks
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2021 Oct/Nov · Paper 1 · Q6 · 1 mark
Marking scheme
Mark scheme — 2021 Paper 1 Q6
Answer: C
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